pFind Studio: a computational solution for mass spectrometry-based proteomics

News

2025 -  2024 -  2023 -  2022 -  2021 -  2020 -  2019 -  2018 -  2017 -  2016 -  2015 -  2014 -  2013 -  2012 -  2011 -  2010 -  2009 - 

2025 更多+



Apr 24, 2025 - Our paper Global analysis of protein and small-molecule substrates of ubiquitin-like proteins (UBLs) has been published on Molecular & Cellular Proteomics.




Mar 30, 2025 - The pFind team climbed the Longquan section of Great Wall.




Mar 22, 2025 - The pFind team organized the Life and Health Sub-forum of the ICT's AI4S symposium.




Feb 11, 2025 - The pFind team came together to celebrate the Lantern Festival.




Jan 22, 2025 - The pFind team held its annual meeting. All pFinders summarized and reported their work in 2024.

2024 更多+



Dec 7, 2024 - The pFind team held a team-building activity, where pFinders enjoyed a harmonious atmosphere and had some pleasant chats.



Nov 26, 2024 - pFinders organized a small seminar, and Yong-Qing Tan (谭永卿) and Kai-Fei Wang (王凯菲) presented their research proposals.



Oct 25-26, 2024 - pFinders participated in a joint meeting and visited Beijing WTown (古北水镇) with their partners from Chao Liu (刘超) Lab of BUAA.



Sep 25-27, 2024 - Hao Chi, Wen-Feng Zeng, Ya-Ping Peng and Peng-Zhi Mao gave presentations at Shanghai Institute of Immunity and Infection, CAS.

Hao Chi introduced the protein and peptide identification methods based on tandem mass spectrometry data.

Wen-Feng Zeng introduced the Glycoproteomics.

Ya-Ping Peng introduced the use of pFind.

Peng-Zhi Mao introduced the use of pLink.



Aug 12, 2024 - The pFind team held its semi-annual meeting. All pFinders summarized and reported their work in the first half of 2024.

2023 更多+



Dec 29, 2023 - Our paper PepPre: Promote Peptide Identification Using Accurate and Comprehensive Precursors has been published on J. Proteome Res.



Nov 4, 2023 - Dr. Wen-Feng Zeng introduced his research and life status, and his return to Beijing led to a joyful reunion of pfinders!





Oct 17, 2023 - Professor Hao Chi taught a proteomics data analysis course at the Yanqi Lake Campus of the University of Chinese Academy of Sciences.





Sep 23-27, 2023 - pFinders attended the 12th CNHUPO and learned a lot. Kai-Fei Wang and Ya-Ping Peng won the Poster Award. And during these days, pFinders took the opportunity to visit the Chengdu Giant Panda Breeding& Research Base to see cute pandas together.





Sep 1-3, 2023 - The CXMS training of CNCP-2023, co-hosted by the Meng-Qiu Dong (董梦秋) Lab of NIBS and pFind Team, has been successfully completed!



2022 更多+



Dec 17 & 18, 2022 - All pfinders celebrated the 20th anniversary (2002-2022), and 13 speakers were invited to share their wonderful reports. Everyone who attended the meeting gave enthusiastic responses. Awaiting our upcoming reunion!



Dec 7, 2022 - Prof. Chao Liu's group and Dr. Wen-Feng Zeng published an article entitled "pGlycoQuant with a deep residual network for quantitative glycoproteomics at intact glycopeptide level" on Nature Communications.




Nov 24, 2022 - Dr. Wen-Feng Zeng published an article entitled "AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics" on Nature Communications.




Nov 21, 2022 - During the pandemic, thank UCAS for the gift bundle!





Oct 29, 2022 - Our paper A universal database reduction method based on the sequence tag strategy to facilitate large-scale database search in proteomics has been published on International Journal of Mass Spectrometry.



2021 更多+



Dec 30, 2021 - pFinders participated in a joint meeting and visited Lakeside Great Wall (水长城) with their partners from Meng-Qiu Dong (董梦秋) Lab of NIBS.





Nov 25, 2021 - Our paper Precise, fast and comprehensive analysis of intact glycopeptides and modified glycans with pGlyco3 has been published on Nature Methods.



Nov 2, 2021 - Our paper pValid 2: A deep learning based validation method for peptide identification in shotgun proteomics with increased discriminating power has been published on Journal of Proteomics.




Oct 15, 2021 - Prof. He (贺思敏) and Prof. Chi (迟浩) won the Promotion of Science award of CNHUPO.





Sep 20, 2021 - pFinders celebrated the Mid-Autumn Festival together.

2020 更多+



December 4, 2020 - The pFinders attended the 2nd Westlake Symposium for Clinical Mass Spectrometry online.





October 30, 2020 - The pFinders attended the 2020 ICT-NIBS CXMS prospective academic seminar and communicated.





September 14, 2020 - Our paper GameTag: A New Sequence Tag Generation Algorithm Based on Cooperative Game Theory has been accepted for publication by Proteomics. Congratulations.



August 29, 2020 - The 10th Ann. Academic Forum of China Workshop on Computational Proteomics was held online.





August 25, 2020 - Master students Xinyi Xu and Xi Wang passed the dissertation defense online.



2019 更多+



December 29-31, 2019 - Associate Professor Hao Chi and Master Student Zhuohong Wei visited Feng Ge's lab and communicated.



Dcember 22 28, 2019 - The pFind students attended the National Center for the Performing Arts Open Day and had fun.





November 28, 2019 - The pFind team listened to a concert of Andre Rieu online.





October 17-20, 2019 - The pFind team attended China National Computer Congress (CNCC) 2019. We won the first prize for Technical Invention Award. Congratulations.




September 4, 2019 - Master students Xin-Yi Xu and Zhuo-Hong Wei went bunjee jumping. Congratulations.



2018 更多+



December 25-27, 2018 - Associate Professor Hao Chi and Ph.D. student Zhen-Lin Chen visited DICP and gave two reports about Open-pFind and pLink 2.




November 18, 2018 - Ph.D. student Zhen-Lin Chen attended the Bio-MS forum and gave a report.




pFinders attended the 10th CNHUPO. November 15-17, 2018 - pFinders attended the 10th CNHUPO. 

Rui-Xiang Sun, Hao Chi, Chao Liu, Wen-Feng Zeng and Zhen-Lin Chen gave reports in CNHUPO EDUCATION DAY. Hao Chi and Wen-Feng Zeng also gave reports in Parallel Sessions.




October 24, 2018 - Dr. Daniel Figeys from University of Ottawa visited the pFind team again and gave a report.




October 8, 2018 - Our paper Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine has been accepted for publication by the Nature Biotechnology. Congratulations!


2017 更多+



December 8-11, 2017 - pFinders attended the 3rd China Mass Spectrometry Symposium. Associate Professor Rui-Xiang Sun gave a report.




November 13, 2017 - Our paper pSite: Amino Acid Confidence Evaluation for Quality Control of De Novo Peptide Sequencing and Modification Site Localization has been accepted for publication by the Journal of proteome research.




November 10, 2017 - Our paper pDeep: Predicting MS/MS Spectra of Peptides with Deep Learning

 has been accepted for publication by the Analytical Chemistry.



November 8, 2017 - Dr. Yue Xuan and other friends from Thermo Fisher visited the pFind team and gave a report.





October 12, 2017 - Associate Professor Cheng Lin from Boston University visited the pFind team and gave a report.

2016 更多+



December 26, 2016 - Our paper Open-pNovo: De Novo Peptide Sequencing with Thousands of Protein Modifications has been accepted for publication by the Journal of proteome research.




November 29, 2016 - Wen-Feng Zeng passed the dissertation defense. He studied glycoproteomics in the pFind team.





October 21, 2016 - Assistant Professor Xiaowen Liu from Indian University-Purdue University Indianapolis visited the pFind team.




September 21, 2016 - Professor David L. Tabb from Stellenbosch University visited the pFind team and gave a report.



August 19-20, 2016 - Hao Yang attended the 14th CJK Bioinformatics Training Course & Symposium.

2015 更多+



November 22, 2015 - We held a small seminar on proteogenomics.

Seven experts in this field attended this seminar and gave reports. These experts were Feng Ge, Jing Li, Heng-Liang Wang, Ying-Chun Wang, Ping Xu, Gong Zhang and Li Zhu.



November 22, 2015 - Kun Zhang passed the dissertation defense.





October 17-19, 2015 - pFinders attended the 2nd CNMS. 

Associate Professor Rui-Xiang Sun and Dr. Chao Liu gave reports.




September 2, 2015 - Dr. Yuan Zhou from Dalian Institute of Chemical Physics, CAS visited pFind team.



August 10-12, 2015 - Lan Luo attended the 13th CJK Bioinformatics Training Course.

2014 更多+



Dec. 15, 2014 - Dr. Zuo-Fei Yuan returns home. He got Ph.D. degree in June, 2012. Now he works as a postdoctor at University of Pennsylvania.





Nov. 12-13, 2014 - The Third China Workshop on Computational Proteomics successfully completed.

We give thanks to all experts for their good presentations and to all participants for their support. Click here for more details.




June 17-21, 2014 - Kun Zhang attended Korea-Japan-China Bioinformatics Training Course.

He gave a report titled "Identifying novel genes and gene refinements in Thermoanaerobacter tengcongensis".




June 14-20, 2014 - Shengbo Fan and Wu Long attended American Society for Mass Spectrometry (ASMS) 2014




May 19, 2014 - CNCP.ict.ac.cn is online now.   

第三届中国计算蛋白质组学研讨会将于2014年11月12日、13日在中科院计算所举行。
截止2014年5月15日,CNCP-2014组委会已经邀请到如下10位学者作大会报告(汉语拼音字母序):
丁琛 葛英 林诚 刘晓文 汤海旭 王春光 王恒樑 应万涛 钟鸿英 周虎
欢迎海内外专家学者莅临指导!
访问CNCP2014获取更多关于中国计算蛋白质组学研讨会的信息!

2013 更多+



Dec. 17, 2013 - 2013计算所生物信息组学术交流会在计算所四层召开。

会议由迟浩博士主持,韩仁敏、张静蓉、张昆、邬龙、罗海涛、卜德超、张海仓和许情8位同学做了精彩的报告,贺思敏、卜东波、孙瑞祥、张法、赵屹五位老师以及生物信息组的全体同学参加。大家从选题新颖性、方法创新性、表述清晰程度、以及实验效果四个方面对报告进行了评比,最终张静蓉同学的报告《Iterative methods in large field electron microscope tomography and its parallelization》获得最高的分数。

计算所生物信息组学术交流会每年举办一次,旨在增进各研究组间的学术交流,鼓励青年人勇于创新、积极拼搏、善于表达。会上各位老师、同学给报告人提出了很多有意义的建议,会后大家进行了热烈的讨论。该交流会得到了大家的一致好评,达到了预期效果。

图 张静蓉同学介绍CT成像技术




Dec. 1, 2013 - Kun He and Long Wu get their Master Degrees!




Sep. 7, 2013 - The 8th CNHUPO Annual Congress successfully completed.

Teacher Sun and ChiHao made reports in this congress and we learned a lot. Click here for more details.



Apr. 8, 2013 - Dr. Bandeira and Jeong of UCSD visited pFinders.

2012 更多+



Nov. 16, 2012 - The Second China Workshop on Computational Proteomics successfully completed.

 We give thanks to all experts for their good presentations and to all participants for their support. Click here for more details.



Sep. 1, 2012 - The Tenth Uppsala Conference on Electron Capture and Transfer Dissociation is online.

This international conference is co-organized by the Institute of Computing Technology (ICT), Chinese Academy of Sciences and National Institute of Biological Sciences (NIBS),China, which will be held in Beijing Friendship Hotel during Feb.17 to 21, 2013.
Click http://uppcon2013.csp.escience.cn/ for details.



Aug. 29, 2012 - CNCP.ict.ac.cn is online now.   

第二届中国计算蛋白质组学研讨会将于2012年11月14日、15日在中科院计算所举行。
本次会议的特邀专家有(汉语拼音字母序):
邓海腾 关慎恒 何增有 胡良海 蒋太交 赖仞 李婧 林熙宁 马斌 苗龙 宁康 谭敏佳 田志新
王柏臣 王立顺 薛宇 杨兵 杨胜勇 张弓 张扬 张红雨 张纪阳 张京芬 章冰 赵雁林
欢迎海内外专家学者莅临指导!
访问CNCP2010获取更多关于第一届中国计算蛋白质组学研讨会的信息!


July 9, 2012 - The paper Identification of cross-linked peptides from complex samples has been published online in Nature Methods.

        2012年7月8日,北京生命科学研究所董梦秋实验室与中科院计算技术研究所贺思敏教授领导的pFind研究团队合作在《Nautre Methods》在线发表题为“Identification of Cross-linked Peptides from Complex Samples”的文章。
        蛋白质化学交联结合质谱鉴定技术(chemical cross-linking of proteins coupled with mass spectrometry analysis,CXMS)能够提供丰富的蛋白质折叠与蛋白质相互作用的信息。该技术能够帮助测定蛋白质的结构以及蛋白质复合物亚基之间相互作用的界面。
        CXMS技术虽然只能提供鉴定到的交联氨基酸之间的空间距离信息,但不需要蛋白质晶体,也不需要大量的高度纯化的蛋白,是对现有的结构生物学技术的补充。CXMS还有望与蛋白质免疫共沉淀或pull-down 结合,辨识直接相互作用的蛋白。CXMS对蛋白样品的量与纯度要求较低,实验周期短,具备广泛的适用性。
        在这篇论文中,研究人员报告了一套完整的基于高精度质谱鉴定化学交联肽段的方法。他们优化了CXMS的各个实验环节,并与中科院计算所合作开发了化学交联多肽的鉴定软件pLink。
        pLink可以处理复杂样品如全细胞裂解液的CXMS数据,能够有效估算交联多肽鉴定的假阳性率,并且对谱图进行自动标注。研究人员用体外纯化的简单蛋白质样品、大的蛋白质复合物、免疫共沉淀样品、以及大肠杆菌和秀丽线虫全细胞裂解液,充分证明了CXMS和pLink软件的有效性。


Jun. 27, 2012 - Dr. Zhi-Xin Tian of DICP visited pFinders.

2011 更多+



Nov. 3, 2011 - Our paper pParse: a method for accurate determination of monoisotopic peaks in high-resolution mass spectra has been accepted for publication by the journal Proteomics.



Jun. 9, 2011 (Munich, Germany) - Zuo-Fei Yuan attended MaxQuant Summer School 2012.

2010 更多+



Dec. 13, 2010 (Dalian, China)  - pFinders visited Dr. Li-Hua Zhang and Zhen Liang of DICP.



Nov. 30, 2010 - Dr. Marshall Bern visited pFinders.



Nov. 12, 2010 - The First China Workshop on Computational Proteomics successfully completed. We give thanks to all experts for their good presentations and to all participants for their support. Click here for more details.



Oct. 19, 2010 - Dr. Daniel Figeys and Hu-Zhou visited pFinders.



Oct. 11, 2010 - Dr. Peipei Ping visited pFinders.

2009 更多+



Oct. 23, 2009 (Dalian, China) - pFinders visited Dr. Li-Hua Zhang and Zhen Liang of DICP.



Oct. 15, 2008 - John Yates visited pFinders and Dong Lab.